Kollberg B, Aly A, Johansson C
Acta Physiol Scand. 1981 Oct;113(2):189-92. doi: 10.1111/j.1748-1716.1981.tb06881.x.
Exogenous prostaglandins have specific protective effects on the gastric mucosa called cytoprotection which is proposed to be connected to the stimulatory effects of prostaglandins on the gastric nonparietal secretions. The protection by oral prostaglandin E2 (PGE2) against indomethacin-induced gastric erosions was studied in the rat, as was the effect on the protection of blocking the gastric alkaline secretion by acetazolamide. PGE2 reduced dose-dependently the indomethacin gastric erosion formation, confirming previous results from others. Acetazolamide caused very little damage when given alone but potentiated the indomethacin erosion formation in a dose-related way. PGE2 was less protective or without effect against lesions caused by indomethacin when given together with acetazolamide, but protection could be obtained by increasing the doses of PGE2. Indomethacin and acetazolamide are both blockers of the gastric bicarbonate secretion, which is stimulated by PGE2. The potentiation of indomethacin induced lesions by acetazolamide and the antagonistic actions between acetazolamide and PGE2 on mucosal protection are compatible with the hypothesis that stimulation of the alkaline secretion is one mechanism of cytoprotection of the gastric mucosa by PGE2.
外源性前列腺素对胃黏膜具有特定的保护作用，称为细胞保护作用，据推测这与前列腺素对胃非壁细胞分泌的刺激作用有关。在大鼠中研究了口服前列腺素E2（PGE2）对吲哚美辛诱导的胃糜烂的保护作用，以及乙酰唑胺阻断胃碱性分泌对这种保护作用的影响。PGE2剂量依赖性地减少了吲哚美辛诱导的胃糜烂形成，证实了其他人先前的研究结果。单独给予乙酰唑胺时造成的损伤很小，但以剂量相关的方式增强了吲哚美辛诱导的糜烂形成。当与乙酰唑胺一起给予时，PGE2对吲哚美辛引起的损伤保护作用减弱或无效，但通过增加PGE2的剂量可以获得保护作用。吲哚美辛和乙酰唑胺都是胃碳酸氢盐分泌的阻滞剂，而PGE2可刺激胃碳酸氢盐分泌。乙酰唑胺增强吲哚美辛诱导的损伤以及乙酰唑胺与PGE2在黏膜保护上的拮抗作用，与碱性分泌的刺激是PGE2对胃黏膜细胞保护的一种机制这一假设相符。
