Lidbeck J, Månson J C
Acta Med Scand. 1981;210(4):293-8. doi: 10.1111/j.0954-6820.1981.tb09818.x.
Progression of bone marrow abnormalities in 12 patients with malignant (fatal) hemopoietic dysplasia (HD) was evaluated retrospectively in sequential bone marrow samples, using a simple morphological scoring technique. Special attention was paid to alterations in cytological abnormalities in the myeloid series. Patients who developed acute myeloid leukemia showed increasing scores during the clinical course and a rapid final increase in particularly myeloid nucleolar abnormalities. Patients who did not develop overt myeloid leukemia but died from bleeding and/or infection had low and stable scoring and showed no progression of cytological abnormalities. Repeated evaluation, especially of cytological changes in the bone marrow, and morphological scoring might be useful as predictive tools to estimate the risk of a leukemic transformation in some patients with HD.
采用一种简单的形态学评分技术，对12例恶性（致死性）造血发育异常（HD）患者的连续骨髓样本进行回顾性评估，以观察骨髓异常的进展情况。特别关注髓系细胞异常的变化。发生急性髓系白血病的患者在临床过程中评分增加，尤其是髓系核仁异常在末期迅速增加。未发生明显髓系白血病但死于出血和/或感染的患者评分低且稳定，细胞学异常无进展。重复评估，尤其是对骨髓细胞学变化和形态学评分，可能作为预测工具，用于估计一些HD患者发生白血病转化的风险。
