迟缓真杆菌对胆汁酸的转化作用。
Transformation of bile acids by Eubacterium lentum.
作者信息
Hirano S, Masuda N
出版信息
Appl Environ Microbiol. 1981 Nov;42(5):912-5. doi: 10.1128/aem.42.5.912-915.1981.
Abstract
A group of fecal isolates identified as Eubacterium lentum elaborated 3 alpha-, 7 alpha-, and 12 alpha-dehydrogenases and also an epimerizing enzyme(s) for the 3 alpha-hydroxy group. The activities of the enzymes, however, were variably manifested according to the kind of bile acid substrate and the oxygen tension under which the reaction occurred.
摘要
一组被鉴定为迟缓真杆菌的粪便分离株产生了3α-、7α-和12α-脱氢酶，以及一种针对3α-羟基的差向异构酶。然而，这些酶的活性根据胆汁酸底物的种类以及反应发生时的氧张力而有不同表现。
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1
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Microbiol Immunol. 1981;25(3):271-82. doi: 10.1111/j.1348-0421.1981.tb00029.x.
2
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Appl Environ Microbiol. 1981 Mar;41(3):737-45. doi: 10.1128/aem.41.3.737-745.1981.
3
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