[Effect of prostaglandins E1, E2, F2 alpha and prostacyclin on the process of local thrombus formation following microvessel wall damage by lasers].

The internal surface of the rat mesentery venule was exposed to laser. Microthrombogenesis was studied from the time of maximal thrombus formation, time of the first embolism occurrence, thrombus area, and rate of embolism formation. Intravenous infusion of PGE1 and prostacyclin led to the reduction of microhemostasis as shown by all the characteristics. PGF2 alpha, on the contrary, exhibited prothrombogenous activity; PGE2 was little effective. Comparison of the active concentrations of the substances administered has demonstrated prostacyclin to have the most powerful action.