单核细胞白血病中单核细胞和前单核细胞的特征与功能

Characteristics and functions of monocytes and promonocytes in monocytic leukemia.

作者信息

van Furth R, van Zwet T L, van den Barselaar M T, Leijh P C

出版信息

Haematol Blood Transfus. 1981;27:175-8. doi: 10.1007/978-3-642-81696-3_19.

Abstract

The characteristics of mononuclear phagocytes (promonocytes and bone-marrow and blood monocytes) of 27 patients with acute or chronic monocytic leukemia were studied. The percentages of promonocytes with peroxidase and esterase activity and of cells with Fcgamma and C3b receptors showed some divergence from those found in normal individuals. The phagocytic activity of monocytes and their ability to kill ingested Staphylococcus aureus were not decreased in this group of patients. The 3H-thymidine-labeling index of the promonocytes did not differ greatly from normal values, which indicates that the percentage of dividing promonocytes had not increased. The very low labeling index of the circulating monocytes means that these cells do not divide and therefore cannot be blast cells or monoblasts.

摘要

对27例急性或慢性单核细胞白血病患者的单核吞噬细胞（原单核细胞、骨髓及血液中的单核细胞）特征进行了研究。有过氧化物酶和酯酶活性的原单核细胞以及具有Fcγ和C3b受体的细胞的百分比与正常个体中发现的有所不同。在这组患者中，单核细胞的吞噬活性及其杀灭摄入的金黄色葡萄球菌的能力并未降低。原单核细胞的3H-胸腺嘧啶核苷标记指数与正常值差异不大，这表明正在分裂的原单核细胞的百分比并未增加。循环单核细胞的标记指数非常低，这意味着这些细胞不会分裂，因此不可能是母细胞或原单核细胞。