Bird E D, Anton A H
Psychiatry Res. 1982 Feb;6(1):1-6. doi: 10.1016/0165-1781(82)90031-2.
Interpretation of data on the possible relationship between changes in endogenous putative transmitters and neuropsychiatric disorders may be altered by the use of neuroleptic agents. As one approach to this problem, we attempted to simulate the situation in man by measuring the changes in dopamine in basal ganglia of monkeys during the chronic (20 months) administration of an antipsychotic phenothiazine. Unexpectedly, a biphasic response was obtained: dopamine increased after 2 months but was markedly reduced after 20 months. Perhaps, dyskinesia is related to this biphasic effect of the antipsychotic phenothiazines.
使用抗精神病药物可能会改变对内源性假定递质变化与神经精神疾病之间潜在关系的数据解读。作为解决这个问题的一种方法，我们试图通过测量猴子基底神经节中多巴胺在长期（20个月）服用抗精神病吩噻嗪期间的变化来模拟人类的情况。出乎意料的是，得到了一种双相反应：2个月后多巴胺增加，但20个月后显著减少。也许，运动障碍与抗精神病吩噻嗪的这种双相效应有关。
