[细胞内钠和钙作为原发性高血压的遗传标志物]

[Intracellular sodium and calcium as a genetic marker in essential hypertension].

作者信息

Dorst K G, Zidek W, Losse H, Zumkley H, Wollnik S, Vetter H

出版信息

Schweiz Med Wochenschr. 1981 Dec 12;111(50):1964-6.

Abstract

In 33 normotensive probands with a familial disposition to hypertension and in 18 normotensives without a family history of hypertension, aged 15 to 24 years, intracellular Na+ and Ca2+ activity in red blood cells was determined by ion-selective electrodes. The activities represent the free, i.e. unbound intracellular fraction of each ion. In the group with a family history of hypertension the mean intracellular Na+ activity was 9.74 +/- 1.43 mmol/l and clearly exceeded that in the group without predisposition to hypertension, which was 7.74 +/- 1.06 mmol/l. Even larger differences were found in mean intracellular Ca2+ activity (9.54 +/- 9.56 mumol/l in the group with familial disposition and 1.87 +/- 3.47 mumol/l in the control group). However, due to the relatively wide range of the values, especially with respect to the Ca2+ activities in probands with familial disposition to hypertension, the values from the two groups overlapped. The results suggest that elevation of intracellular Na+ and Ca2+ activity may be evidence for a genetically determined later development of hypertension.

摘要

在33名有高血压家族倾向的血压正常的受试者以及18名无高血压家族史的血压正常者（年龄在15至24岁之间）中，通过离子选择电极测定了红细胞内的Na⁺和Ca²⁺活性。这些活性代表了每种离子的游离即未结合的细胞内部分。在有高血压家族史的组中，平均细胞内Na⁺活性为9.74±1.43 mmol/L，明显超过无高血压倾向组，后者为7.74±1.06 mmol/L。在平均细胞内Ca²⁺活性方面发现了更大的差异（有家族倾向组为9.54±9.56 μmol/L，对照组为1.87±3.47 μmol/L）。然而，由于数值范围相对较宽，特别是对于有高血压家族倾向的受试者的Ca²⁺活性，两组的值有重叠。结果表明，细胞内Na⁺和Ca²⁺活性升高可能是高血压遗传决定的后期发展的证据。