人类白细胞抗原B8抗原与抗磷脂酶A1同种免疫

HLA-B8 antigens and anti-PLa1 allo-immunization.

作者信息

Reznikoff-Etievant M F, Dangu C, Lobet R

出版信息

Tissue Antigens. 1981 Jul;18(1):66-8. doi: 10.1111/j.1399-0039.1981.tb01364.x.

DOI:10.1111/j.1399-0039.1981.tb01364.x

Abstract

HLA-A-B-C and DR typing was performed on sixteen individuals whose PLA1 platelet group was negative. Ten of them were immunostimulated with PLA1 antigen by pregnancy or transfusion; six of them were responders and developed an anti-PLA1 antibody. A high incidence of HLA-B8 antigen was observed in that group of responders. This observation is supported by five other cases of allo-immunization reported in previous papers.

摘要

对16名PLA1血小板组呈阴性的个体进行了HLA - A - B - C和DR分型。其中10人因怀孕或输血而受到PLA1抗原免疫刺激；他们中有6人产生反应并产生了抗PLA1抗体。在该反应者组中观察到HLA - B8抗原的高发生率。此前文献报道的其他5例同种免疫病例也支持了这一观察结果。