急性单核细胞白血病并发儿童局限性尤因肉瘤联合治疗
Acute monocytic leukemia complicating combined-modality therapy for localized childhood Ewing's sarcoma.
作者信息
Schmitt-Gräff A, Jürgens H, Göbel U, Ritter J, Lübbesmeier A, Borchard F
出版信息
J Cancer Res Clin Oncol. 1981;102(1):93-7. doi: 10.1007/BF00410538.
Abstract
Rapidly fatal acute monocytic leukemia occurred in an 11-year-old by 33 months after the beginning of irradiation and chemotherapy for non-metastatic pelvic Ewing's sarcoma. At autopsy, no recurrent primary disease was seen. An analysis of this case together with a review of the literature suggests therapy-related leukemogenesis. Thus, the decline in mortality rate for childhood cancer may be accompanied by an increased incidence of second neoplasms in cured children having the potential of a normal life span.
摘要
一名11岁儿童在接受非转移性骨盆尤文肉瘤放疗和化疗开始33个月后发生了迅速致命的急性单核细胞白血病。尸检时，未发现原发性疾病复发。对该病例的分析以及文献回顾提示存在治疗相关的白血病发生。因此，儿童癌症死亡率的下降可能伴随着有正常寿命潜力的治愈儿童中第二肿瘤发病率的增加。
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