McTaggart H S, Imlah P, Head K W
J Natl Cancer Inst. 1982 Feb;68(2):239-48.
The survival times from birth of 39 entire male Large White pigs with hereditary lymphosarcoma (L/S) were significantly shorter than those of 76 affected females. The survival times of 19 male castrates were for the most part intermediate between those for entire males and females. Analysis of the cause of death revealed that pigs with L/S (L/S-P) were more likely than pigs without L/S to die from colibacillosis, but this disease showed to sex predisposition. In uncomplicated deaths from L/S, weights of splanchnic lymph nodes, spleen, and thymus were greatest in females. The cell-mediated and humoral antibody responses of L/S-P were significantly poorer against 2,4-dinitrofluorobenzene (DNFB) and sheep red blood cells, poorer against skin homografts, but better against bovine serum albumin than those of healthy littermates. Healthy females had stronger DNFB reactions than did healthy males or castrates. Castrated L/S-P responded to DNFB better than did females and significantly better than did entire males.
39头患有遗传性淋巴肉瘤（L/S）的完整雄性大白猪从出生起的存活时间显著短于76头患病雌性大白猪。19头去势雄性大白猪的存活时间大多介于完整雄性和雌性之间。死因分析表明，患有L/S的猪（L/S-P）比未患L/S的猪更易死于大肠杆菌病，但这种疾病无性别倾向。在因L/S导致的无并发症死亡中，雌性的内脏淋巴结、脾脏和胸腺重量最大。L/S-P对2,4-二硝基氟苯（DNFB）和绵羊红细胞的细胞介导免疫反应和体液抗体反应明显比健康同窝仔猪差，对皮肤同种异体移植物的反应较差，但对牛血清白蛋白的反应较好。健康雌性对DNFB的反应比健康雄性或去势雄性更强。去势的L/S-P对DNFB的反应比雌性好，且显著优于完整雄性。
