Houghton J A, Houghton P J, Webber B L
J Natl Cancer Inst. 1982 Mar;68(3):437-43.
Eleven surgical specimens of childhood rhabdomyosarcoma (RMS), two bone marrow samples, and cells from ascitic fluid from 1 patient were implanted sc into immune-deprived inbred CBA/CaJ mice. From these, seven lines of RMS were obtained as xenografts, each retaining the histologic characteristics of the tumor of origin and human lactate dehydrogenase isozymes; these represented 6 of the 11 surgical specimens, whereas one line originated from the transplanted cells from ascitic fluid. It was concluded that children RMS has a fairly high frequency of heterotransplantability in this system and that such a laboratory model may prove useful in the development of new therapeutic regimens in this disease.
将11例儿童横纹肌肉瘤（RMS）手术标本、2份骨髓样本以及1例患者腹水细胞皮下植入免疫缺陷的近交系CBA/CaJ小鼠体内。从中获得了7株RMS异种移植瘤系，每株均保留了原发肿瘤的组织学特征及人乳酸脱氢酶同工酶；这些代表了11例手术标本中的6例，而1株来源于腹水移植细胞。得出的结论是，儿童RMS在该系统中具有相当高的异种移植成功率，并且这样的实验室模型可能在该疾病新治疗方案的开发中证明是有用的。
