Epithelial-myoepithelial carcinoma of intercalated duct origin. A clinicopathologic and ultrastructural assessment of sixteen cases.

A clinicopathologic and ultrastructural analysis of sixteen cases of epithelial-myoepithelial carcinoma of intercalated duct origin was undertaken, together with a review and correlation of eight previously reported cases. The neoplasm is found predominantly in women, with the majority occurring in the seventh and eighth decades of life. Most of these tumors occurred in the parotid gland. Five patients had one or more recurrences, and one patient died of tumor. Histologically, these tumors are composed of two cell types, generally exhibiting a glandular or ductlike arrangement. Ultrastructural findings confirm the duality of the cell population.