患有自发性特发性范科尼综合征的犬类肾脏膜对脯氨酸和葡萄糖的转运
Proline and glucose transport by renal membranes from dogs with spontaneous idiopathic Fanconi syndrome.
作者信息
Medow M S, Reynolds R, Bovee K C, Segal S
出版信息
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7769-72. doi: 10.1073/pnas.78.12.7769.
Abstract
The uptake of proline and glucose by renal brush border membrane vesicles isolated from Basenji dogs exhibiting a spontaneous Fanconi syndrome was examined. The magnitude of the 1-min, Na+-gradient uptake of proline (0.02 mM) and glucose (1.0 mM) by vesicles from affected dog kidney was lower than normal. Concentration-dependent 15-sec uptake in vesicles from normal and affected dogs reveals a two-component transport system for proline and glucose. Kinetic analysis shows altered Km and Vmax values for both proline and glucose transport in the affected dogs. The data suggest that, in this model of Fanconi syndrome, the defective renal reabsorption of proline and glucose is associated with an alteration of luminal transport system.
摘要
对患有自发性范科尼综合征的巴森吉犬分离出的肾刷状缘膜囊泡对脯氨酸和葡萄糖的摄取进行了检测。患病犬肾脏囊泡对脯氨酸（0.02 mM）和葡萄糖（1.0 mM）的1分钟Na⁺梯度摄取量低于正常水平。正常和患病犬囊泡中浓度依赖性的15秒摄取显示脯氨酸和葡萄糖存在双组分转运系统。动力学分析表明，患病犬脯氨酸和葡萄糖转运的Km和Vmax值均发生改变。数据表明，在这个范科尼综合征模型中，脯氨酸和葡萄糖的肾重吸收缺陷与管腔转运系统的改变有关。
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