Bostofte E, Legarth J
Acta Obstet Gynecol Scand. 1981;60(6):575-8. doi: 10.3109/00016348109155489.
In 116 patients, abortion was induced in midtrimester by intra-amniotic administration of 20% hypertonic saline and 25 mg prostaglandin F2 alpha. Within 60 hours 113 aborted (success rate 97.4%). Of these 68.1% had aborted within 24 hours and 92.9% within 48 hours. Thirteen patients who had not aborted within 24 or 48 hours were treated with oxytocin drip. It is concluded that the combination studied is an effective abortifacient in midtrimester and that the injection-abortion time is reasonable, the great majority aborting within 48 hours. No live fetuses were delivered, and the complication rate was acceptable.
对116例患者在妊娠中期通过羊膜腔内注射20%高渗盐水和25毫克前列腺素F2α引产。60小时内113例流产（成功率97.4%）。其中68.1%在24小时内流产，92.9%在48小时内流产。13例在24小时或48小时内未流产的患者接受了催产素静脉滴注治疗。结论是，所研究的联合用药是妊娠中期有效的堕胎药，引产至流产的时间合理，绝大多数在48小时内流产。无活胎娩出，并发症发生率可接受。
