Shah-Reddy I, Kessel D H, Chou T H, Mirchandani I, Khilanani U
Am J Hematol. 1982 Feb;12(1):29-37. doi: 10.1002/ajh.2830120105.
Plasma fucosyltransferase activity was evaluated as an indicator of an impending blastic transformation in 25 patients with chronic granulocytic leukemia (CGL). Fifteen age-and sex-matched controls were also studied. The level of enzyme activity was significantly higher in the plasma of patients with blastic transformation (1,630 +/- 570 units) compared with steady chronic granulocytic leukemia (509 +/- 110 units) and normal controls (354 +/- 57 units). In three patients with CGL, a rise in fucosyltransferase activity preceded any other clinical or laboratory parameter of blastic transformation by 16-20 weeks.
评估了25例慢性粒细胞白血病（CGL）患者的血浆岩藻糖基转移酶活性，以此作为即将发生原始细胞转化的指标。还研究了15名年龄和性别匹配的对照者。与稳定期慢性粒细胞白血病患者（509±110单位）和正常对照者（354±57单位）相比，发生原始细胞转化的患者血浆中的酶活性水平显著更高（1630±570单位）。在3例慢性粒细胞白血病患者中，岩藻糖基转移酶活性升高比原始细胞转化的任何其他临床或实验室参数提前了16 - 20周。
