Magnusson B, Bergman M, Bergman B, Söremark R
Scand J Dent Res. 1982 Apr;90(2):163-7. doi: 10.1111/j.1600-0722.1982.tb01540.x.
Test pieces from five cobalt-chromium casting alloys intended for use in removable partial dentures were attached to the skin of 10 women with known allergy to nickel. Patch tests were also performed with nickel and cobalt salts. Nine of the 10 women showed clear-cut or strong patch test reactions to the alloy with 7% nickel, one patient also to one of the other alloys (less than 1% nickel). In five patients with contact allergy reactions to both nickel and cobalt salts mild or marked responses to some of the other alloys were observed. Corresponding observations were made in three out of the five patients with contact allergy reactions to nickel salt but not cobalt salt.
选取了五种打算用于可摘局部义齿的钴铬铸造合金的试件，将其贴附在10名已知对镍过敏的女性皮肤上。还用镍盐和钴盐进行了斑贴试验。10名女性中有9名对含7%镍的合金表现出明确或强烈的斑贴试验反应，1名患者对另一种合金（镍含量低于1%）也有反应。在5名对镍盐和钴盐均有接触过敏反应的患者中，观察到对其他一些合金有轻度或明显反应。在5名对镍盐有接触过敏反应但对钴盐无反应的患者中，有3名也有相应观察结果。
