酵母注射诱导的脑内甲硫氨酸脑啡肽变化与镇痛的关系。

Relationship of yeast-injection induced changes in brain met-enkephalin and analgesia.

作者信息

Chipkin R E, Billard W, Iorio L C, Barnett A

出版信息

Peptides. 1982 Jan-Feb;3(1):31-5. doi: 10.1016/0196-9781(82)90138-3.

Abstract

Subplantar injection of Brewer's yeast induces a hyperalgesia that is associated with an increase in the level of striatal Met-enkephalin (ME); there was no change in the hypothalamus of periaqueductal gray. To test the relationship between striatal ME and analgesia, naloxone (10, 3, 0.5 mg/kg, SC) or thiorphan (100 micrograms, ICV) were administered. Neither drug caused a potentiation or a reduction in the hypersensitivity. These data suggest that an increase in striatal does not result in altered pain sensitivity in this model.

摘要

足底注射啤酒酵母可诱发痛觉过敏，这与纹状体中甲硫氨酸脑啡肽（ME）水平升高有关；中脑导水管周围灰质的下丘脑无变化。为了测试纹状体ME与镇痛之间的关系，给予纳洛酮（10、3、0.5mg/kg，皮下注射）或硫喷妥（100微克，脑室内注射）。两种药物均未引起超敏反应的增强或降低。这些数据表明，在该模型中纹状体ME的增加不会导致疼痛敏感性的改变。