Reiertsen O, Jerve F, Fylling P
Prostaglandins Leukot Med. 1982 Jan;8(1):31-5. doi: 10.1016/0262-1746(82)90124-x.
Thirty healthy women with early first trimester pregnancy applying for legal abortion were given five vagitories containing 1 mg 16,16-dimethyl-trans delta 2 prostaglandin E1 (16,16-dimethyl PGE1). They were instructed to take one vagitory every third hour. The treatment was evaluated at follow-up visits after one, two and four weeks. Complete abortion was recorded in 27 cases. The pregnancy test was still positive after two weeks in three women, who underwent surgical termination, and were recorded as failures. The most common side-effects were bleeding, pain and gastrointestinal symptoms. No serious side-effects were recorded. Repeated administration of vagitories containing 1 mg 16,16-dimethyl PGE1 seems to be a safe and effective method of "menstrual extraction". The efficacy should be increased and the rate and intensity of side effects decreased if "menstrual extraction" is to compete with conventional dilatation and curettage.
30名申请合法堕胎的孕早期健康女性被给予5枚含1毫克16,16-二甲基反式δ2前列腺素E1（16,16-二甲基PGE1）的阴道栓剂。她们被指示每三小时使用一枚阴道栓剂。在1周、2周和4周后的随访中对治疗效果进行评估。27例记录为完全流产。3名女性在2周后妊娠试验仍为阳性，她们接受了手术终止妊娠，并被记录为失败病例。最常见的副作用是出血、疼痛和胃肠道症状。未记录到严重副作用。重复使用含1毫克16,16-二甲基PGE1的阴道栓剂似乎是一种安全有效的“月经提取”方法。如果“月经提取”要与传统的刮宫术竞争，其疗效应提高，副作用的发生率和强度应降低。
