Silverstone L M
J Public Health Dent. 1982 Winter;42(1):42-53. doi: 10.1111/j.1752-7325.1982.tb03786.x.
Remineralization occurs naturally during the formation of a carious lesion in human dental enamel and is seen in the form of two of the four classical histological zones of the lesion. Exposure of small lesions to a synthetic calcifying in vitro results in a significant increase in remineralization of the lesion. The degree of remineralization achieved depends upon the presence of fluoride ions in the calcifying fluid and its degree of supersaturation. It appears that only low levels of fluoride are required to trigger the mechanism of remineralization; raising the fluoride level further does not result in a greater degree of remineralization. The calcium ion concentration of the calcifying fluid is critical with respect to determining which components are supersaturated and which in turn determines the degree of remineralization achieved. With levels of 3.0 mM calcium only the superficial region of the lesion is remineralized whereas with a calcium concentration of 1.0 mM, remineralization occurs in depth. It is hoped that studies on remineralization phenomena will provide further insight into the mechanisms of caries formation and be the basis for a more powerful and effective form of caries prevention.
再矿化在人类牙釉质龋损形成过程中自然发生，表现为龋损四个经典组织学区域中的两个区域。将小龋损暴露于体外合成钙化环境中会导致龋损再矿化显著增加。实现的再矿化程度取决于钙化液中氟离子的存在及其过饱和度。似乎仅需低水平的氟就能触发再矿化机制；进一步提高氟水平并不会导致更高程度的再矿化。钙化液中的钙离子浓度对于确定哪些成分过饱和至关重要，而这又反过来决定了实现的再矿化程度。当钙离子浓度为3.0 mM时，仅龋损的表层区域会发生再矿化，而当钙离子浓度为1.0 mM时，再矿化会深入发生。希望对再矿化现象的研究能进一步深入了解龋齿形成机制，并成为更强大、有效的龋齿预防形式的基础。
