Yam L T
South Med J. 1982 Jul;75(7):870-2. doi: 10.1097/00007611-198207000-00028.
A patient had chronic neutrophilic leukemia. The characteristic clinical features of this disease include long-standing neutrophilia in the absence of an underlying disease, marked granulocytic hyperplasia in the bone marrow, increased leukocyte alkaline phosphatase activity, and absence of Philadelphia chromosome in the marrow cells. The patient survived for six years but eventually died of acute erythroleukemia. Neutrophilic leukemia although rare, possesses characteristic features sufficient to be considered a distinct clinical and hematologic entity.
一名患者患有慢性嗜中性粒细胞白血病。该疾病的特征性临床特征包括在无潜在疾病的情况下长期存在嗜中性粒细胞增多、骨髓中显著的粒细胞增生、白细胞碱性磷酸酶活性增加以及骨髓细胞中无费城染色体。该患者存活了六年，但最终死于急性红白血病。嗜中性粒细胞白血病虽然罕见，但具有足以被视为一种独特的临床和血液学实体的特征。
