溶血磷脂酰胆碱梯度对淋巴细胞的立体特异性化学吸引作用。
Stereospecific chemoattraction of lymphoblastic cells by gradients of lysophosphatidylcholine.
作者信息
Hoffman R D, Kligerman M, Sundt T M, Anderson N D, Shin H S
出版信息
Proc Natl Acad Sci U S A. 1982 May;79(10):3285-9. doi: 10.1073/pnas.79.10.3285.
Human plasma contains chemoattractant activity for cultured cells from the mouse thymic lymphoma 6C3HED and also for lymphoblasts from concanavalin A-stimulated mouse spleen cells. A major portion of the attractant activity for both cell types could be attributed to plasma lysophosphatidylcholine. Studies on synthetic lysophosphatides showed that polar head group structure, acyl chain length, and stereochemical configuration are important determinants for attractant activity.
人血浆对来自小鼠胸腺淋巴瘤6C3HED的培养细胞以及对伴刀豆球蛋白A刺激的小鼠脾细胞的成淋巴细胞具有趋化活性。这两种细胞类型的趋化活性的主要部分可归因于血浆溶血磷脂酰胆碱。对合成溶血磷脂的研究表明，极性头部基团结构、酰基链长度和立体化学构型是趋化活性的重要决定因素。
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