Frasca J M, Garfinkel L
Nutr Cancer. 1981;3(2):72-4. doi: 10.1080/01635588109513704.
The inhibitory effect of 13-cis-retinoic acid was tested in conjunction with ethyl carbamate (urethane) induced murine pulmonary adenomas. Continuous feeding of the retinoic acid for 20 weeks did not significantly reduce the number of surface adenomas. No physical evidence of toxicity due to the vitamin A analog was observed in any of the mice. All mice showed a steady weight gain during the 20-week period, and there was no evidence of eye lesions, hemorrhage, bone fractures, fur changes or lethargy.
在乙氨基甲酸乙酯（尿烷）诱导的小鼠肺腺瘤实验中测试了13-顺式维甲酸的抑制作用。连续20周喂食维甲酸并未显著减少表面腺瘤的数量。在任何一只小鼠中均未观察到由于这种维生素A类似物导致的毒性的物理证据。所有小鼠在20周期间体重均稳步增加，并且没有眼部病变、出血、骨折、皮毛变化或嗜睡的证据。
