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[镝作为可激活示踪剂在牙齿结构研究中的应用]

[Use of dysprosium considered as an activable tracer in the study of tooth structures].

作者信息

Vernois V, Deschamps N, Revel G, Septier D, Goldberg M

出版信息

J Biol Buccale. 1982 Jun;10(2):135-45.

PMID:6956571
Abstract

After 32 days of administration to rats of dysprosium in drinking water, this element has been studied by neutron activation analysis in the intra-oral part of the incisors as well as in the molar crowns. This element was absent in the intra-osseous parts of the incisors, the femurs and the liver. After intravenous injection of 13 mg or 26 mg of Dy in several doses over 32 days, this element was found in the incisor formation and maturation zones as well as in the part having erupted in the oral cavity. It was also found in the molars, the femurs and the liver. The structural study has shown that no cytotoxic effect was observed with the dysprosium doses used. Dentinogenesis and amelogenesis were not disturbed. The final structures were homogeneous. By comparing the two administration ways of dysprosium we have at our disposal a study model using an inducible tracer of the incorporation of adsorption of a mineral element in dental structures during early or late maturations.

摘要

在用含镝的饮用水对大鼠给药32天后,通过中子活化分析研究了该元素在切牙口腔内部分以及磨牙牙冠中的情况。在切牙、股骨和肝脏的骨内部分未发现该元素。在32天内分几次静脉注射13毫克或26毫克镝后,在切牙形成和成熟区以及已萌出到口腔中的部分发现了该元素。在磨牙、股骨和肝脏中也发现了该元素。结构研究表明,所用镝剂量未观察到细胞毒性作用。牙本质形成和釉质形成未受干扰。最终结构均匀。通过比较镝的两种给药方式,我们拥有了一个研究模型,可用于追踪在牙齿结构早期或晚期成熟过程中矿物元素吸附掺入情况的诱导性示踪剂。

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