正常人和囊性纤维化患者下颌下唾液的脂质成分

Lipid composition of submandibular saliva from normal and cystic fibrosis individuals.

作者信息

Slomiany B L, Aono M, Murty V L, Slomiany A, Levine M J, Tabak L A

出版信息

J Dent Res. 1982 Oct;61(10):1163-6. doi: 10.1177/00220345820610101001.

DOI:10.1177/00220345820610101001

Abstract

The submandibular saliva of patients with cystic fibrosis was found to contain about 66% more lipids/100 ml of saliva than that of normal individuals and exhibited elevated levels of neutral lipids, phospholipids, and glycolipids. No significant differences were noted in the proportions of individual neutral lipid and phospholipid components present in both types of samples. The glycolipids of normal saliva consisted entirely of glyceroglucolipids, whereas those of cystic fibrosis saliva, in addition to glyceroglucolipids, also contained small amounts of glycosphingolipids. These quantitative and qualitative differences may affect the physicochemical properties of the secretion.

摘要

研究发现，囊性纤维化患者的颌下唾液中每100毫升唾液所含脂质比正常人多约66%，且中性脂质、磷脂和糖脂水平升高。两种样本中单个中性脂质和磷脂成分的比例没有显著差异。正常唾液中的糖脂完全由甘油葡糖脂组成，而囊性纤维化患者唾液中的糖脂除甘油葡糖脂外，还含有少量鞘糖脂。这些定量和定性差异可能会影响分泌物的物理化学性质。