Jaworkowsky L, Grant H
Folia Haematol Int Mag Klin Morphol Blutforsch. 1977;104(1):11-23.
The amount of lysozyme in the leukocytes of 47 patients with different forms of leukaemia and 6 healthy persons was investigated. The lysozyme determination was carried out in the lysate of isolated leukocytes obtained after freezing and thawing it seven times. The results expressed in microgram per 10(6) cells were compared with the simultaneously determined lysozyme concentration of serum and urine. A substantial reduction of the lysozyme amount as compared with the normal value (3.1 microgram/10(6) cells) was determined in the leukocytes of patients suffering from chronic lymphatic leukaemia, acute lymphatic leukaemia and the blastic crisis of chronic myeloid leukaemia. Different amounts of lysozyme ranging from extremely low ones to strongly elevated ones were found in leukocytes taken from patients with acute myeloblastic and chronic monocytic leukaemia. In many cases there was a lack of correlation between the lysozyme content of leukocytes on the one hand and that of serum and urine on the other hand. Possible causes underlying this lack of correlation are discussed.
对47例不同类型白血病患者及6名健康人的白细胞中的溶菌酶含量进行了研究。溶菌酶的测定是在将分离的白细胞冷冻解冻7次后获得的裂解物中进行的。以每10⁶个细胞中微克数表示的结果与同时测定的血清和尿液中的溶菌酶浓度进行了比较。与正常值（3.1微克/10⁶个细胞）相比，慢性淋巴细胞白血病、急性淋巴细胞白血病和慢性粒细胞白血病急变期患者的白细胞中溶菌酶含量显著降低。在急性髓细胞性白血病和慢性单核细胞白血病患者的白细胞中发现了不同量的溶菌酶，从极低到显著升高不等。在许多情况下，白细胞中的溶菌酶含量与血清和尿液中的溶菌酶含量之间缺乏相关性。讨论了这种缺乏相关性的可能原因。
