小鼠体内3-苯氧基苯甲酸和拟除虫菊酯类杀虫剂氯氰菊酯代谢中的牛磺酸共轭作用。
Taurine conjugation in metabolism of 3-phenoxybenzoic acid and the pyrethroid insecticide cypermethrin in mouse.
作者信息
Hutson D H, Casida J E
出版信息
Xenobiotica. 1978 Sep;8(9):565-71. doi: 10.3109/00498257809061256.
PMID:695699
Abstract
- A substantial proportion of the radioactivity of an oral dose (1-20 mg/kg) of 3-phenoxy [14C] benzoic acid and the pyrethroid insecticide trans- and cis-[aryl-14C] cypermethrin (an alpha-cyano-3-phenoxybenzyl ester) is eliminated rapidly in urine of mice. 2. The major urinary metabolite of these compounds in two strains of mice is N-(3-phenoxybenzoyl)taurine. 3. Neither 3-phenoxybenzoic acid nor cypermethrin gives a taurine conjugate in rats. 4. Benzoic acid gives no taurine conjugate in mice.
摘要
- 口服剂量为1 - 20毫克/千克的3 - 苯氧基[¹⁴C]苯甲酸及拟除虫菊酯杀虫剂反式和顺式[芳基 - ¹⁴C]氯氰菊酯（一种α - 氰基 - 3 - 苯氧基苄酯）的很大一部分放射性在小鼠尿液中迅速消除。2. 这两种化合物在两株小鼠中的主要尿液代谢产物是N - （3 - 苯氧基苯甲酰基）牛磺酸。3. 3 - 苯氧基苯甲酸和氯氰菊酯在大鼠体内均未产生牛磺酸共轭物。4. 苯甲酸在小鼠体内未产生牛磺酸共轭物。
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