Yoo D, Lessin L S
Am J Med. 1982 Oct;73(4):539-42. doi: 10.1016/0002-9343(82)90333-3.
Bone marrow mast cell content was evaluated by a semiquantitative method in 22 marrow specimens from 20 patients with preleukemic syndrome and was compared with 21 marrow specimens from iron-deficient control subjects. Results indicate a statistically significant increase of bone marrow mast cell content in patients with preleukemic syndrome in comparison to control subjects (p less than or equal to 0.0005). Two of 20 preleukemic patients converted to acute myeloblastic leukemia and conversion was accompanied by a significant decrease of bone marrow mast cell content. Our findings indicate that bone marrow mast cell content can be reproducibly quantitated and represents an additional morphologic criterion for diagnosis of the preleukemic syndrome.
采用半定量方法对20例白血病前期综合征患者的22份骨髓标本中的骨髓肥大细胞含量进行了评估，并与21份缺铁对照受试者的骨髓标本进行了比较。结果表明，与对照受试者相比，白血病前期综合征患者的骨髓肥大细胞含量有统计学意义的增加（p≤0.0005）。20例白血病前期患者中有2例转化为急性髓细胞白血病，转化过程伴随着骨髓肥大细胞含量的显著降低。我们的研究结果表明，骨髓肥大细胞含量可以重复定量，是诊断白血病前期综合征的一项额外形态学标准。
