枸橼酸氯米芬对大鼠排卵的阻断作用以及人绒毛膜促性腺激素或前列腺素F2α对其的逆转作用。
Blockade of ovulation by clomiphene citrate and its reversal by human chorionic gonadotropin or prostaglandin F2 alpha in rats.
作者信息
Chatterjee R, Chatterjee A
出版信息
Prostaglandins Leukot Med. 1982 Jul;9(1):55-60. doi: 10.1016/0262-1746(82)90072-5.
PMID:6957892
Abstract
Clomiphene citrate (clomid), a nonsteroidal estrogenic compound, was found to be effective in blocking ovulation in rats when scheduled at a dose of 3.0 mg/kg on day 2 or late day 4 of the estrus cycle. Treatment with hCG or prostaglandin F2 alpha (PGF2 alpha) concurrently with clomid consistently reversed the antiovulatory effect of clomid. The possible mode of action of clomid in the interruption of ovulation has been discussed.
摘要
枸橼酸氯米芬（克罗米酚）是一种非甾体雌激素化合物，当在发情周期的第2天或第4天晚期按3.0毫克/千克的剂量给药时，发现它对阻断大鼠排卵有效。与氯米芬同时使用人绒毛膜促性腺激素（hCG）或前列腺素F2α（PGF2α）进行治疗，始终能逆转氯米芬的抗排卵作用。已经讨论了氯米芬在中断排卵中可能的作用方式。
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