King D, Dowdy S, Jack R, Gardner R, Edwards P
Psychiatry Res. 1982 Aug;7(1):93-9. doi: 10.1016/0165-1781(82)90057-9.
An abnormal dexamethasone suppression test (DST) result, a sensitive and specific marker for endogenous depression, was found to be associated with an antidepressant response to sleep deprivation in patients who met DSM-III criteria for Major Depressive Episode regardless of whether they met criteria for melancholia or psychotic subtypes of this disorder. These findings support previous reports of an association between an abnormal DST result and antidepressant effects of sleep deprivation in depressed patients. Our results extend the positive association between an abnormal DST result and the antidepressant response to sleep deprivation to include depressed patients who are clinically nonmelancholic during their current episode but who have an abnormal DST result.
地塞米松抑制试验（DST）结果异常是内源性抑郁症的一个敏感且特异的标志物，研究发现，符合《精神疾病诊断与统计手册》第三版（DSM-III）中重度抑郁发作标准的患者，无论是否符合该疾病的 melancholia 或精神病性亚型标准，其DST结果异常都与对睡眠剥夺的抗抑郁反应相关。这些发现支持了先前关于DST结果异常与抑郁症患者睡眠剥夺的抗抑郁作用之间存在关联的报道。我们的研究结果将DST结果异常与睡眠剥夺的抗抑郁反应之间的正相关扩展至包括当前发作期临床无 melancholia 表现但DST结果异常的抑郁症患者。
