Hacker N F, Castaldok T W, Morrow C P, Ballon S C
Aust N Z J Obstet Gynaecol. 1982 May;22(2):103-6. doi: 10.1111/j.1479-828x.1982.tb01415.x.
A 64-year-old patient underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy in October, 1978 for a Stage IA, grade 2 papillary adenocarcinoma of the endometrium. Peritoneal washings contained numerous malignant cells, although the tumor invaded the myometrium only superficially. Two weeks after operation, 12 mCi of P32 were instilled into the peritoneal cavity. In May, 1979, laparotomy was performed for clinical obstruction of the small intestine and revealed diffuse peritoneal, omental, and hepatic metastases. Radiation changes involved the terminal ileum, ascending and sigmoid colon; an ileorectal fistula was also identified. The factors that might cause malignant cells to be present in the peritoneal cavity and the ideal treatment of such patients have yet to be determined. THe risk of intraperitoneal P32 might outweigh its benefits.
1978年10月，一名64岁患者因子宫内膜IA期2级乳头状腺癌接受了全腹子宫切除术和双侧输卵管卵巢切除术。尽管肿瘤仅浅肌层浸润，但腹腔冲洗液中发现大量恶性细胞。术后两周，向腹腔内注入12毫居里的P32。1979年5月，因临床诊断小肠梗阻行剖腹术，发现弥漫性腹膜、网膜和肝转移。放射性改变累及回肠末端、升结肠和乙状结肠；还发现了回直肠瘘。可能导致腹腔内出现恶性细胞的因素以及此类患者的理想治疗方法尚未确定。腹腔内注入P32的风险可能超过其益处。
