Kunze K, Gothe R
Z Parasitenkd. 1978 Aug 7;56(3):275-85. doi: 10.1007/BF00931720.
Investigations on the impulse propagation and the pattern of amplitudes of toxically by Argas (Persicargas) walkerae larvae impaired peripheral nerves were carried out under oxygen saturated and anoxic conditions. It was demonstrated, that the maximum nerve conduction velocities of the isolated N. ischiadicus were slightly lowered in the first carbogenic and anoxic phase, in comparison with normal nerves. After the second incubation the conduction velocities were, however, almost the same or even higher. The survival times of the nerves after anoxic exposure, which were determined by the temporal persistence of the potentials, revealed that this neurophysiological parameter always resulted in a higher value for the damaged nerves after every two anoxic phases. The diseased nerves therefore tolerate anoxia longer and better than do healthy nerves in respect to their excitability and in their function of impulse propagation. From these in vitro investigations it is concluded that the noxious substance responsible for the paralysis is not cell-bound, but circulates humorally. The toxin possesses membranophilic properties, but its somatic linkage is very labile.
在氧气饱和及缺氧条件下，对受波斯锐缘蜱幼虫毒性损害的外周神经的冲动传导及振幅模式进行了研究。结果表明，与正常神经相比，分离出的坐骨神经在首个充氧期和缺氧期的最大神经传导速度略有降低。然而，在第二次孵育后，传导速度几乎相同甚至更高。通过电位的持续时间确定缺氧暴露后神经的存活时间，结果显示，在每两个缺氧期后，该神经生理参数在受损神经中总是产生更高的值。因此，就其兴奋性和冲动传导功能而言，患病神经比健康神经更能耐受缺氧且耐受时间更长。从这些体外研究得出的结论是，导致麻痹的有害物质并非细胞结合型，而是通过体液循环。该毒素具有亲膜特性，但其与体细胞的连接非常不稳定。
