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Metabolism of daunorubicin in sensitive and resistant Ehrlich ascites tumor cells. Determination by high pressure liquid chromatography.

作者信息

Londos-Gagliardi D, Baurain R, Robert J, Aubel-Sadron G

出版信息

Cancer Chemother Pharmacol. 1982;9(1):45-8. doi: 10.1007/BF00296761.

DOI:10.1007/BF00296761
PMID:6958392
Abstract

The intracellular metabolism of daunorubicin (DNR) has been studied in sensitive and resistant Ehrlich ascites tumor (EAT) cells. The subcellular localization of metabolites has been followed by normal-phase and reverse-phase high-pressure liquid chromatography (HPLC). The metabolism of DNR by either sensitive or resistant EAT cells is not significant; unmetabolized DNR is always the main intracellular compound. Daunorubicinol (DOL) accounts for less than 5% after 24 h and an unidentified product is also observed. This highly apolar compound, having an intrinsic fluorescence one order of magnitude greater than that of DNR is formed in acellular conditions and could be a chemical artifact. DNR and DOL are mainly associated with DNA-containing fractions. No significant differences can be observed in the metabolism of DNR in sensitive and resistant EAT cells.

摘要

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本文引用的文献

1
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Subcellular localization of daunorubicin in sensitive and resistant Ehrlich ascites tumor cells.
柔红霉素在敏感和耐药艾氏腹水瘤细胞中的亚细胞定位
Eur J Cancer (1965). 1980 Jun;16(6):849-54. doi: 10.1016/0014-2964(80)90138-3.
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Mechanism of daunorubicin inhibition of hog spleen acid deoxyribonuclease.柔红霉素抑制猪脾酸性脱氧核糖核酸酶的机制
Mol Pharmacol. 1975 Sep;11(5):640-6.
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10
Experimentally developed cellular resistance to daunomycin. Resistance mechanisms, the daunomycin-pump and cross resistance to adriamycin, vincristine and vinblastine.实验诱导的细胞对柔红霉素的耐药性。耐药机制、柔红霉素泵以及对阿霉素、长春新碱和长春花碱的交叉耐药性。
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