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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lumbers E R, Potter E K

Clin Exp Pharmacol Physiol Suppl. 1982;7:45-9.

In unanaesthetized sheep, transitory hypertension caused by intravenous angiotensin II and angiotensin III is not associated with a progressive increase in pulse interval, while hypertension caused by intravenous vasopressin produces a progressive increase in pulse interval. 2. Experiments in anaesthetized dogs showed that the three peptides do not alter the sensitivity of the carotid sinus baroreceptors. When arterial pressure was increased by angiotensin II and III, cardiac vagal efferent discharge did not increase as much as it did when blood pressure was raised by intravenous phenylephine or inflation of an intra-aortic balloon--often vagal discharge did not increase at all, or even fell. Vasopressin on the other hand produced a sustained and marked increase in cardiac vagal efferent nerve activity; this was in excess of the increase evoked when other agents were used to raise blood pressure. 3. Thus the three peptides can centrally modulate vagal control of heart rate.

在未麻醉的绵羊中，静脉注射血管紧张素II和血管紧张素III所引起的短暂性高血压与脉搏间期的逐渐增加无关，而静脉注射血管加压素所引起的高血压则会使脉搏间期逐渐增加。2. 对麻醉犬进行的实验表明，这三种肽不会改变颈动脉窦压力感受器的敏感性。当血管紧张素II和III使动脉血压升高时，心脏迷走神经传出放电的增加幅度不如静脉注射去氧肾上腺素或主动脉内气囊充气使血压升高时那么大——迷走神经放电常常根本不增加，甚至下降。另一方面，血管加压素会使心脏迷走神经传出神经活动持续且显著增加；这超过了使用其他药物升高血压时所引起的增加幅度。3. 因此，这三种肽可以在中枢调节迷走神经对心率的控制。

Lumbers E R, Potter E K

Clin Exp Pharmacol Physiol Suppl. 1982;7:45-9.

In unanaesthetized sheep, transitory hypertension caused by intravenous angiotensin II and angiotensin III is not associated with a progressive increase in pulse interval, while hypertension caused by intravenous vasopressin produces a progressive increase in pulse interval. 2. Experiments in anaesthetized dogs showed that the three peptides do not alter the sensitivity of the carotid sinus baroreceptors. When arterial pressure was increased by angiotensin II and III, cardiac vagal efferent discharge did not increase as much as it did when blood pressure was raised by intravenous phenylephine or inflation of an intra-aortic balloon--often vagal discharge did not increase at all, or even fell. Vasopressin on the other hand produced a sustained and marked increase in cardiac vagal efferent nerve activity; this was in excess of the increase evoked when other agents were used to raise blood pressure. 3. Thus the three peptides can centrally modulate vagal control of heart rate.

在未麻醉的绵羊中，静脉注射血管紧张素II和血管紧张素III所引起的短暂性高血压与脉搏间期的逐渐增加无关，而静脉注射血管加压素所引起的高血压则会使脉搏间期逐渐增加。2. 对麻醉犬进行的实验表明，这三种肽不会改变颈动脉窦压力感受器的敏感性。当血管紧张素II和III使动脉血压升高时，心脏迷走神经传出放电的增加幅度不如静脉注射去氧肾上腺素或主动脉内气囊充气使血压升高时那么大——迷走神经放电常常根本不增加，甚至下降。另一方面，血管加压素会使心脏迷走神经传出神经活动持续且显著增加；这超过了使用其他药物升高血压时所引起的增加幅度。3. 因此，这三种肽可以在中枢调节迷走神经对心率的控制。