Khromov-Borisov N V, Borisova G Iu, Aleksandrova I Ia, Gol'dfarb V L, Brovtsyna N B
Zh Vyssh Nerv Deiat Im I P Pavlova. 1978 Jul-Aug;28(4):761-4.
Influence of ethymisol (bismethylamid of 1-ethylimidasol-4,5-dicarbonic acid) on learning and retention of habit was studied in experiments on rats by the method of active conditioned avoidance of electrical stimulation. At the same time optimal conformation form of the drug was determined by the method of proton magnetic resonance and by means of infrared spectra and theoretical conformation analysis. A single administration of ethymisol in the dose of 3 mg/kg reduced the deficit of the avoidance habit, when tested in 30 and 60 days following learning. A stable conformation of the ethymisol molecule with a planar arrangement of atoms of its heterocycle and amide groups was found in which the interaction of this substance with biological macromolecules was most active. The ethymisol effect on the long-term memory apparently results from a stable facilitation of synaptic transmission based on stabilization of spatial structure of biological macromolecules in the given conformation.
采用主动条件性回避电刺激的方法，在大鼠实验中研究了乙硫异烟胺（1-乙基咪唑-4,5-二甲酸的双甲酰胺）对学习和习惯保持的影响。同时，通过质子磁共振法、红外光谱法和理论构象分析法确定了该药物的最佳构象形式。以3mg/kg的剂量单次给予乙硫异烟胺，在学习后30天和60天进行测试时，可减少回避习惯的缺陷。发现乙硫异烟胺分子具有稳定的构象，其杂环和酰胺基团的原子呈平面排列，在这种构象中该物质与生物大分子的相互作用最为活跃。乙硫异烟胺对长期记忆的影响显然源于基于给定构象中生物大分子空间结构的稳定而对突触传递的稳定促进作用。
