Singer H S, Tune L E, Butler I J, Zaczek R, Coyle J T
Adv Neurol. 1982;35:177-83.
Our studies have demonstrated that TS patients show a high degree of sensitivity to butyrophenone blockade of dopaminergic receptors. The clinical response to extremely low serum levels of haloperidol includes sedating side effects, as well as therapeutic effects. These clinical changes are associated with significant increases in CSF HVA levels, which were abnormally decreased before treatment. CSF HIAA levels tended to be normal and did not change with haloperidol treatment. These results lend additional support to the hypothesis that TS is related to supersensitivity of dopaminergic receptors.
我们的研究表明，抽动秽语综合征（TS）患者对丁酰苯类药物阻断多巴胺能受体表现出高度敏感性。对极低血清水平氟哌啶醇的临床反应包括镇静副作用以及治疗效果。这些临床变化与脑脊液中高香草酸（HVA）水平显著升高相关，治疗前该水平异常降低。脑脊液中5-羟吲哚乙酸（HIAA）水平趋于正常，且未随氟哌啶醇治疗而改变。这些结果为TS与多巴胺能受体超敏相关的假说提供了更多支持。
