氢化可的松对大鼠肺中前列腺素E2代谢的影响。

The effect of hydrocortisone on the metabolism of PGE2 in rat lungs.

作者信息

Puustinen T, Uotila P

出版信息

Prostaglandins Leukot Med. 1982 Nov;9(5):479-82. doi: 10.1016/0262-1746(82)90027-0.

Abstract

Hydrocortisone pretreatment of male rats daily for five days (2 or 10 mg/kg, s.c.) had no significant effect on the total inactivation of prostaglandin E2 in isolated perfused rat lungs or on the activity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase in the 100.000 x g supernatant fraction of homogenized lungs. Nor did pulmonary infusion of hydrocortisone (0.1 or 1 microM in the perfusion medium) have any effect on the metabolism of PGE2 in isolated rat lungs. The present study indicates that pulmonary inactivation of PGE2 is not changed by hydrocortisone in rat lungs.

摘要

对雄性大鼠连续五天每日进行氢化可的松预处理（皮下注射，剂量为2或10毫克/千克），对离体灌注大鼠肺中前列腺素E2的总失活或对匀浆肺100,000×g上清液组分中NAD⁺依赖性15-羟基前列腺素脱氢酶的活性均无显著影响。向灌注液中肺内输注氢化可的松（0.1或1微摩尔/升）对离体大鼠肺中PGE2的代谢也没有任何影响。本研究表明，氢化可的松不会改变大鼠肺中PGE2的肺内失活。