Kather H
Prostaglandins Leukot Med. 1982 Nov;9(5):531-7. doi: 10.1016/0262-1746(82)90034-8.
Prostaglandin E2 (PG E2) has biphasic effects on human fat cell adenylate cyclase with inhibition occurring in the nanomolar concentration range and stimulation at PG E2-concentrations above 1 mumol/l. Sodium ions stimulate the human fat cell adenylate cyclase in a hormone-like manner. The inhibitory component of PG E2-action is markedly augmented by sodium ions. In addition, the monovalent cation, by interfering with the stimulatory component of PG E2 discriminates between the opposing effects of PG E2 suggesting that the antagonistic effects of the E-type prostaglandins are mediated through distinct processes.
前列腺素E2（PGE2）对人脂肪细胞腺苷酸环化酶具有双相作用，在纳摩尔浓度范围内产生抑制作用，而在PGE2浓度高于1微摩尔/升时产生刺激作用。钠离子以激素样方式刺激人脂肪细胞腺苷酸环化酶。钠离子可显著增强PGE2作用的抑制成分。此外，这种单价阳离子通过干扰PGE2的刺激成分，区分了PGE2的相反作用，这表明E型前列腺素的拮抗作用是通过不同的过程介导的。
