Janáky T, Laczi F, László F A
Ann N Y Acad Sci. 1982;394:116-27. doi: 10.1111/j.1749-6632.1982.tb37417.x.
The biological half-lives and organ distribution of tritiated 8-lysine-vasopressin and 1-deamino-8-D-arginine-vasopressin were determined in R-Amsterdam rats and in homozygous and heterozygous Brattleboro rats with hereditary central diabetes insipidus. It was found that the biological half-lives of [3H]LVP and [3H]dDAVP in the Brattleboro rats did not differ significantly from that found in the control R-Amsterdam rats. The half-life of [3H]dDAVP proved longer than that of [3H]LVP in all three groups of animals. In the case of [3H]LVP the highest radioactivities were observed in the neurohypophyses, adenohypophyses, and kidneys of both the R-Amsterdam and Brattleboro rats. The accumulation of tritiated material was higher in the small intestine of the Brattleboro rats than in that of the R-Amsterdam animals. In all three groups of rats, [3H]dDAVP was accumulated to the greatest extent in the kidney and the small intestine. The kidney and small intestine contained less radioactivity in homozygous Brattleboro rats than in the controls. There was only a slight radioactivity accumulation in the adenohypophysis and neurohypophysis. From the results it was concluded that the decrease in the rate of enzymatic decomposition may play a role in the increased duration of antidiuretic action of dDAVP. The results have led to the conclusion that the accelerated elimination of vasopressin and its pathologic organ accumulation are probably not involved in the water metabolism disturbance of Brattleboro rats with hereditary diabetes insipidus.
在R - 阿姆斯特丹大鼠以及患有遗传性中枢性尿崩症的纯合子和杂合子布拉特洛维大鼠中，测定了氚标记的8 - 赖氨酸 - 加压素和1 - 去氨基 - 8 - D - 精氨酸 - 加压素的生物半衰期及器官分布。结果发现，布拉特洛维大鼠体内[³H]LVP和[³H]dDAVP的生物半衰期与对照R - 阿姆斯特丹大鼠相比无显著差异。在所有三组动物中，[³H]dDAVP的半衰期均长于[³H]LVP。对于[³H]LVP，在R - 阿姆斯特丹大鼠和布拉特洛维大鼠的神经垂体、腺垂体和肾脏中观察到最高放射性。布拉特洛维大鼠小肠中氚标记物质的积累高于R - 阿姆斯特丹动物。在所有三组大鼠中，[³H]dDAVP在肾脏和小肠中积累程度最大。纯合子布拉特洛维大鼠的肾脏和小肠中的放射性低于对照组。腺垂体和神经垂体中仅有轻微的放射性积累。从结果得出结论，酶分解速率的降低可能在dDAVP抗利尿作用持续时间延长中起作用。结果还得出结论，加压素的加速消除及其病理性器官积累可能与患有遗传性尿崩症的布拉特洛维大鼠的水代谢紊乱无关。
