Bremner M H, Wright J
Aust J Ophthalmol. 1982 Nov;10(4):255-62. doi: 10.1111/j.1442-9071.1982.tb01626.x.
Modern cytotoxic drugs increase the survival rate of children with Acute Lymphoblastic Leukaemia (ALL): But the eye is a pharmacological sanctuary and after clinical "cure" of the haematological disease the child may be blinded by leukaemic ocular infiltration. This is the history of a child who had had no recurrence of haematological leukaemia for four and a half years but following remission developed central nervous system (CNS) leukaemia followed by leukaemic iridocyclitis in the right eye after 20 months and in the left eye after three years three months from the initial diagnosis of ALL. Prophylactic cranial irradiation is performed on initial haematological diagnosis of ALL. This includes prophylactic irradiation of the posterior segment of the eye and optic nerve. Should this prophylactic irradiation of the posterior segment of the eye and optic nerve be repeated on diagnosis of CNS leukaemia and at specified intervals thereafter with recurrence of CNS leukaemia?
现代细胞毒性药物提高了急性淋巴细胞白血病（ALL）患儿的生存率：但眼睛是一个药物庇护所，在血液疾病临床“治愈”后，患儿可能会因白血病眼部浸润而失明。这是一名患儿的病史，其血液系统白血病已四年半未复发，但在缓解后出现了中枢神经系统（CNS）白血病，在最初诊断为ALL后的20个月右眼出现白血病性虹膜睫状体炎，三年零三个月后左眼出现。在ALL的初始血液学诊断时进行预防性颅脑照射。这包括对眼后段和视神经进行预防性照射。在诊断为CNS白血病时以及此后CNS白血病复发的特定间隔，是否应重复对眼后段和视神经进行这种预防性照射？
