Endo M, Yagi S
Electroencephalogr Clin Neurophysiol Suppl. 1982;36:216-20.
The mechanism of action of dantrolene sodium, a peripherally acting muscle relaxant, is reviewed. It does not alter action potentials or responses of the contractile proteins to Ca. The amount of Ca acting on the contractile proteins during twitch must, therefore, be reduced, but since Ca uptake by the SR is not altered, Ca release from the SR must be reduced by the drug. Other characteristics of this drug and their clinical implications are discussed.
本文综述了外周性肌肉松弛剂丹曲林钠的作用机制。它不会改变动作电位或收缩蛋白对钙的反应。因此，在抽搐期间作用于收缩蛋白的钙量必定减少，但由于肌浆网对钙的摄取未改变，该药物必定减少了肌浆网的钙释放。本文还讨论了该药物的其他特性及其临床意义。
