St Omer F B, Iozzo R V, Casetti P, Dellarolle A C
Acta Hepatogastroenterol (Stuttg). 1978 Aug;25(4):319-21.
A case of Focal Nodular Hyperplasia of the liver in a young woman taking oral contraceptives is described. The parenteral administration of an elevated dosage of progesterone in a concentrated period of time is a remarkable feature of this case. The vascular alterations, which consisted of a marked increase of arterial and venous formations, intimal proliferation, diffused thrombosis, and the presence of large blood spaces recalling "peliosis hepatis" are the most salient microscopic findings. We should not exclude the possibility that these peculiar vascular alterations be the real effect of steroid hormones on a pre-existent hepatic lesion.
本文描述了一例年轻女性口服避孕药后发生肝脏局灶性结节性增生的病例。在一段集中的时间内肠胃外给予高剂量的孕酮是该病例的一个显著特征。血管改变是最显著的微观发现，包括动脉和静脉结构显著增加、内膜增生、弥漫性血栓形成以及存在类似“肝紫癜”的大血腔。我们不应排除这些特殊血管改变可能是类固醇激素对先前存在的肝脏病变产生的实际影响。
