Petrov M, Georgieva V, Velizarova K, Georgiev G, Peĭchev D
Vutr Boles. 1982;21(5):96-103.
One hundred fifty one patients were studied--with acute lymphoblast leukosis (ALL) and acute non-lymphoblast (myelogenic) leukosis (ANLL). The disease had a fulminant course in 118 of the patients studied (21.8%). In 73 patients, out of 118 studied, no treatment effect was obtained (61.9%) and the rest 45 patients developed a complete remission (38.1%). In 10 of the patients with no treatment effect, a partial remission was obtained (8.4%). The remission is more frequent in case of ALL. The younger age, at present, remains the most essential prognostic factor. Partial initial leukose infiltration of the bone marrow was found in some of the patients. The bone marrow aplasia is not an obligatory phase of remission. The latter could develop by a gradual restoration of the normal hematopoiesis. The existence of stages with inducing of leukosis processes is possible that follow the reverse way in remission development. Hemorrhages are the most frequent complications in forms with fulminant course, and the infections--in the rest of the patients.
对151例急性淋巴细胞白血病（ALL）和急性非淋巴细胞（骨髓性）白血病（ANLL）患者进行了研究。在所研究的患者中，118例病情呈暴发性（21.8%）。在这118例患者中，73例未获得治疗效果（61.9%），其余45例患者完全缓解（38.1%）。在未获得治疗效果的患者中，10例获得了部分缓解（8.4%）。ALL患者缓解更为常见。目前，年龄较小仍然是最重要的预后因素。部分患者骨髓存在初期白细胞浸润。骨髓再生障碍并非缓解的必经阶段。缓解可通过正常造血功能的逐渐恢复而发生。在缓解过程中，可能存在白血病诱导阶段，其发展方向与诱导过程相反。出血是暴发性病程类型中最常见的并发症，而感染则是其余患者中最常见的并发症。
