Deleers M, Malaisse W J
Cancer Lett. 1982 Nov-Dec;17(2):135-40. doi: 10.1016/0304-3835(82)90025-8.
Multilamellar liposomes formed of phospholipids bind [20-3H(N)]-phorbol 12,13-dibutyrate, the dissociation constant and maximal binding being comparable to those found in fibroblasts or epidermal cells. The relative capacity of distinct phorbol esters to compete with the labeled ligand was similar to their relative tumor-promoting capacity. It is proposed that the specific binding of phorbol esters to biological material may be accounted for by their insertion in the phospholipid domain of membranes.
由磷脂形成的多层脂质体可结合[20 - 3H(N)] - 佛波醇12,13 - 二丁酸酯，其解离常数和最大结合量与在成纤维细胞或表皮细胞中发现的相当。不同佛波醇酯与标记配体竞争的相对能力与其相对促肿瘤能力相似。有人提出，佛波醇酯与生物材料的特异性结合可能是由于它们插入到膜的磷脂结构域中。
