Gross R, Gerecke D
Wien Klin Wochenschr. 1982 Nov 12;94(21):591-6.
The effective treatment of acute (myeloblastic and lymphoblastic) leukaemias depends on the induction of remissions as well as on the maintenance of these remissions. Whereas the use of anthracyclines and of cytosine arabinoside in different combinations notably increased the rate of induction of remissions, their maintenance was less successful until now. We present a scheme using, beside MTX and 6-MP, modified COAP regimes periodically every 3 months. The follow-up of 26 patients treated in this way is encouraging since nearly one third remained in full haematological remission after 3 years of observation.
急性(髓细胞性和淋巴细胞性)白血病的有效治疗取决于缓解的诱导以及这些缓解的维持。虽然使用不同组合的蒽环类药物和阿糖胞苷显著提高了缓解诱导率,但到目前为止,它们在维持缓解方面效果欠佳。我们提出了一种方案,除了甲氨蝶呤(MTX)和6-巯基嘌呤(6-MP)外,每3个月定期使用改良的COAP方案。对26例采用这种方法治疗的患者进行随访,结果令人鼓舞,因为经过3年观察,近三分之一的患者仍处于完全血液学缓解状态。