Destee A, Jouet J P, Prud'homme M, Devos P, Lambert P, Bauters F, Warot P
Ann Med Interne (Paris). 1982;133(8):604-7.
The course of acute leukaemias, particularly of the lymphoblastic type, is very frequently complicated by the development of neuromeningeal localisations of the disease. They may, more rarely, be presenting initial lesions, their origin being confirmed clinically and/or biologically, but it is exceptional that they remain a strictly isolated expression of the affection. A case is reported of a 16-year-old adolescent with leukaemic meningitis, in whom haematological tests (blood counts, bone marrow smear, iliac medullary biopsy, lymph node biopsy) gave negative results over a period of at least two months. Based on the findings in this case, the significance of early neuromeningeal localisations of acute leukaemias is discussed.
急性白血病，尤其是淋巴细胞型白血病的病程，常常因疾病的神经脑膜局部浸润而复杂化。它们较少可能是首发病变，其起源可通过临床和/或生物学方法得以证实，但它们极少仍为该疾病的一种严格孤立的表现形式。本文报道了一例16岁患白血病性脑膜炎的青少年病例，在至少两个月的时间里，其血液学检查（血细胞计数、骨髓涂片、髂骨髓活检、淋巴结活检）结果均为阴性。基于该病例的发现，本文讨论了急性白血病早期神经脑膜局部浸润的意义。
