Yaffe A, Ehrlich J, Shoshan S
Arch Oral Biol. 1982;27(12):999-1001. doi: 10.1016/0003-9969(82)90002-4.
Second premolars in both upper and lower jaws of 6 dogs were extracted and acrylic resin replicas were made of the roots. Horizontal channels were drilled across the root replica perpendicular to the long axis. Before implantation, the prepared root replicas were immersed in a solution of native collagen. One year after implantation, proliferation of connective tissue and newly-formed viable bone were observed within the channel as well as surrounding the treated implants. All control implants without collagen treatment were rejected leaving chronically inflamed implantation sites.
拔除6只犬上下颌的第二前磨牙，并制作牙根的丙烯酸树脂复制品。在牙根复制品上垂直于长轴钻出水平通道。植入前，将制备好的牙根复制品浸入天然胶原蛋白溶液中。植入一年后，在通道内以及处理过的植入物周围观察到结缔组织增生和新形成的活骨。所有未经胶原蛋白处理的对照植入物均被排斥，留下慢性炎症的植入部位。
