Haruyama H, Shimazaki C, Nakanishi S, Hamami T, Nisio A, Isemura T, Katsume H, Nakagawa M, Ijichi H
Gan To Kagaku Ryoho. 1982 Mar;9(3):516-21.
Anthracycline antibiotics are principal agents in the treatment of acute non-lymphocytic leukemia, although the usefulness are limited by their adverse side effects, especially by the cardiotoxicity. Aclacinomycin A (ACM) is known to be a new anthracycline antibiotic which has been isolated from Streptomyces galilaeus, and its cardiotoxicity on the experimental animal systems was reported to be more than 10 times lower than that of adriamycin. We investigated the cardiotoxicity of ACM on 29 patients with acute leukemia and compared it with daunorubicin (DNR). The measurement of STI (PEP:LVET) has been recommended to be convenient method of assessing the anthracycline cardiotoxicity, but through out analytical study, QTC measurement was proved to be more valuable for the simple and rapid detection of the cardiotoxicity induced by the agents. In comparison with the QTCs in DNR and ACM, the cardiotoxicity of ACM was much lower than that of DNR, and the reversibility of ACM induced cardiotoxicity was much more rapid. Moreover, these effects were observed even in the patients treated with the maximum dose of DNR. Therefore, ACM was expected to be one of the agents of the first choice for the relapsed cases of acute leukemia, especially APL.
蒽环类抗生素是治疗急性非淋巴细胞白血病的主要药物，尽管其效用因不良反应，尤其是心脏毒性而受到限制。阿克拉霉素A（ACM）是一种从加利利链霉菌中分离出来的新型蒽环类抗生素，据报道，其在实验动物系统中的心脏毒性比阿霉素低10倍以上。我们研究了ACM对29例急性白血病患者的心脏毒性，并将其与柔红霉素（DNR）进行了比较。测量STI（PEP:LVET）被推荐为评估蒽环类药物心脏毒性的简便方法，但在整个分析研究中，QTC测量被证明对于简单快速检测药物诱导的心脏毒性更有价值。与DNR和ACM中的QTC相比，ACM的心脏毒性远低于DNR，并且ACM诱导的心脏毒性的可逆性要快得多。此外，即使在接受最大剂量DNR治疗的患者中也观察到了这些效应。因此，ACM有望成为急性白血病复发病例，尤其是急性早幼粒细胞白血病的首选药物之一。
