Saito Y, Muraoka K, Takami M, Hokama Y, Hori T
Gan To Kagaku Ryoho. 1982 Jul;9(6):1081-90.
From the recent progress in immunological study, many authors have reported immune suppression in patients with malignant brain tumors. On the other hand, many factors are considered to influence the patterns of cellular and humoral immune parameters in patients with brain tumors, pre- and post-operatively. We treated the patients with malignant brain tumors using ACNU and PSK pre- and post-operatively, and 4 year survival rate was 35.3% (N: 17) in glioblastomas. We planned this time to measure immune parameters (Ig,lymprocyte number,Lyn and T-cell, Tn) pre- and post-operatively in order to study the immune states of patients. The results were as follows: The most significant finding was the elevated serum level of IgG in longterm survival of the patients with glioblastoma and the reduced one in patients with postoperative death. No other humoral immunocompetence existed except slightly reduced IgM level in the patients with death. Contrary to many previous studies, our research has suggested that humoral immune parameters are considered to be valuable to understand postoperative immune states of patients, and administration of PSK be effective as an immunomodulator.
从免疫学研究的最新进展来看，许多作者都报道了恶性脑肿瘤患者存在免疫抑制。另一方面，术前和术后有许多因素被认为会影响脑肿瘤患者细胞免疫和体液免疫参数的模式。我们对恶性脑肿瘤患者术前和术后使用了阿糖胞苷和云芝多糖，胶质母细胞瘤患者的4年生存率为35.3%（n = 17）。此次我们计划在术前和术后测量免疫参数（免疫球蛋白、淋巴细胞数量、淋巴细胞酪氨酸激酶和T细胞、Tn），以研究患者的免疫状态。结果如下：最显著的发现是胶质母细胞瘤长期存活患者的血清IgG水平升高，而术后死亡患者的血清IgG水平降低。除了死亡患者的IgM水平略有降低外，不存在其他体液免疫活性。与之前的许多研究相反，我们的研究表明，体液免疫参数被认为对于了解患者术后免疫状态具有重要价值，并且云芝多糖作为一种免疫调节剂具有有效的作用。
