正常小鼠和免疫缺陷小鼠中耐受性敏感和耐受性不敏感B细胞的描绘。

Delineation of tolerance-sensitive and tolerance-insensitive B cells in normal and immune defective mice.

作者信息

McKearn J P, Quintáns J

出版信息

J Immunol. 1980 Jan;124(1):77-80.

Abstract

B cells responsive to TNP on various thymus-independent carriers acquire immunocompetence at different times during ontogeny and elicit varying levels of responsiveness in immune-defective CBA/N mice. Such B cells have now been found to display differential tolerance susceptibilities in a hapten-specific in vitro tolerance assay. B lymphocytes from normal neonatal or immune-defective adult CBA/N mice responsive to TNP-lipopolysaccharide were shown to be hypersusceptible to tolerogenesis whereas B cell responses to a second TI antigen, TNP-Brucella abortus, were not rendered tolerant until high concentrations of tolerogen had been presented. Therefore, tolerance hypsersusceptibility is characteristic of a fraction of neonatal and immune-defective adult CBA/N antigen-reactive B lymphocytes.

摘要

对各种胸腺非依赖性载体上的三硝基苯（TNP）有反应的B细胞在个体发育的不同时间获得免疫能力，并在免疫缺陷的CBA/N小鼠中引发不同水平的反应性。现在已经发现，在半抗原特异性的体外耐受试验中，这类B细胞表现出不同的耐受敏感性。对TNP-脂多糖有反应的正常新生或免疫缺陷成年CBA/N小鼠的B淋巴细胞显示对致耐受作用高度敏感，而对第二种胸腺非依赖性抗原TNP-流产布鲁氏菌的B细胞反应，直到给予高浓度的致耐受原才会产生耐受。因此，耐受高度敏感性是新生和免疫缺陷成年CBA/N抗原反应性B淋巴细胞一部分的特征。

相似文献

1

Delineation of tolerance-sensitive and tolerance-insensitive B cells in normal and immune defective mice.正常小鼠和免疫缺陷小鼠中耐受性敏感和耐受性不敏感B细胞的描绘。

J Immunol. 1980 Jan;124(1):77-80.

2

In vitro responses of CBA/N mice: spleen cells of mice with an X-linked defect that precludes immune responses to several thymus-independent antigens can respond to TNP-lipopolysaccharide.CBA/N小鼠的体外反应：具有X连锁缺陷、无法对多种胸腺非依赖性抗原产生免疫反应的小鼠的脾细胞，能够对三硝基苯-脂多糖产生反应。

J Immunol. 1976 Oct;117(4):1363-9.

3

T-independent responses in B cell-defective CBA/N mice to Brucella abortus and to trinitrophenyl (TNP) conjugates of Brucella abortus.B细胞缺陷的CBA/N小鼠对流产布鲁氏菌以及流产布鲁氏菌的三硝基苯基（TNP）偶联物的非T细胞依赖性反应。

Eur J Immunol. 1978 Jul;8(7):459-63. doi: 10.1002/eji.1830080703.

4

Analysis of the B cell subpopulations influenced by allogeneic effect factor. I. MHC restricted enhancement of b cell responses to thymic-independent antigens, types 1 and 2, in normal and CBA/N mice.同种异体效应因子对B细胞亚群的影响分析。I. 正常和CBA/N小鼠中MHC限制增强B细胞对1型和2型胸腺非依赖性抗原的反应。

J Immunol. 1983 Feb;130(2):632-6.

5

The effect of second signals on the induction of B cell tolerance: failure of helper T cells to block tolerance induction.第二信号对B细胞耐受性诱导的影响：辅助性T细胞无法阻断耐受性诱导。

Eur J Immunol. 1981 Jul;11(7):550-6. doi: 10.1002/eji.1830110706.

6

Defective B cell tolerance induction in New Zealand black mice. I. Macrophage independence and comparison with other autoimmune strains.新西兰黑鼠中B细胞耐受性诱导缺陷。I. 巨噬细胞非依赖性及与其他自身免疫品系的比较。

J Immunol. 1983 Dec;131(6):2630-4.

7

The immune response of CBA/N mice and their F1 hybrids to 2,4,6-trinitrophenylated (TNP) antigens. I. Analysis of the response to TNP-coupled lipopolysaccharide in vivo and at the clonal level.CBA/N小鼠及其F1杂种对2,4,6-三硝基苯化（TNP）抗原的免疫反应。I. 体内和克隆水平对TNP偶联脂多糖反应的分析。

Eur J Immunol. 1979 Jan;9(1):67-71. doi: 10.1002/eji.1830090114.

8

Ontogeny of susceptibility of mouse splenic B cells to tolerance induction in vitro by TNP-D-GL.小鼠脾脏B细胞体外对TNP-D-GL诱导耐受敏感性的个体发生

Eur J Immunol. 1979 Jan;9(1):76-80. doi: 10.1002/eji.1830090116.

9

The induction of hapten-specific immunologic tolerance and immunity in B lymphocytes. IV. Induction of TNP-specific unresponsiveness in vitro with serum from tolerant mice.B淋巴细胞中半抗原特异性免疫耐受与免疫的诱导。IV. 用耐受小鼠血清在体外诱导TNP特异性无反应性

J Immunol. 1978 Oct;121(4):1558-65.

10

The induction of hapten-specific immunologic tolerance and immunity in B lymphocytes. III. In vitro evaluation of TNP-specific tolerance and evidence for B cell deletion.

J Immunol. 1978 Jul;121(1):245-54.

引用本文的文献

1

Late clonal selection and expansion of the TEPC-15 germ-line specificity.TEPC-15种系特异性的晚期克隆选择与扩增。

J Exp Med. 1980 Nov 1;152(5):1262-73. doi: 10.1084/jem.152.5.1262.

2

Role of variable region gene expression and environmental selection in determining the antiphosphorylcholine B cell repertoire.可变区基因表达和环境选择在决定抗磷酸胆碱B细胞库中的作用。

J Exp Med. 1983 Dec 1;158(6):1948-61. doi: 10.1084/jem.158.6.1948.

3

Regulation by complementary idiotypes. Ig protects the clone producing it.通过互补独特型进行调节。免疫球蛋白保护产生它的克隆。

J Exp Med. 1981 Jun 1;153(6):1377-90. doi: 10.1084/jem.153.6.1377.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。