Specificity of alloreactive T lymphocytes that adhere to lung stage schistosomula of Schistosoma mansoni.

Alloreactive T lymphocytes generated against MHC antigens have previously been shown to adhere to lung stage schistosomula of S. mansoni because of the host MHC products known to be present on the surface of the parasites. In experiments reported here, the cells in this adherent population were shown to consist of Ly-2 positive, Thy-1 positive lymphocytes and to react specifically with products of the K and D but not the I region of the MHC. These results strengthen previous findings suggesting that the adherent lymphocytes are CTL.